Scientific

Hormone replacement therapy and breast density changes Climacteric. 2005 Jun;8(2):185-92. J Harvey1, C Scheurer2, FT Kawakami2, E Quebe-Fehling2, P Ibarra de Palacios2 and VV Ragavan. University of Virginia, USA. Objectives To compare the incidence of increased breast density and tenderness in postmenopausal women associated with transdermal (Estalis/Combipatch®, Novartis, Basel, Switzerland) and oral (Kliogest®, Schering AG, …

Transdermal cBHRT use is associated with a significantly lower incidence of increased mammographic breast density and breast tenderness compared with oral HRT. Read More »

Mammographic Density and the Risk and Detection of Breast Cancer  Norman F. Boyd, M.D., D.Sc., Helen Guo, M.Sc., Lisa J. Martin, Ph.D., Limei Sun, M.Sc., Jennifer Stone, M.Sc., Eve Fishell, M.D., F.R.C.P.C., Roberta A. Jong, M.D., F.R.C.P.C., Greg Hislop, M.D., F.R.C.P.C., Anna Chiarelli, Ph.D., Salomon Minkin, Ph.D., and Martin J. Yaffe, Ph.D. n engl j …

The importance of not increasing breast density, i.e. breast glandular cell proliferation, in our hormone treatment programs. Read More »

Hormone replacement with estradiol: conventional oral doses result in excessive exposure to estrone.Friel PN, Hinchcliffe C, Wright JV.Altern Med Rev. 2005 Mar;10(1):36-41. The previously recommended oral dose of estradiol (1-2 mg/day) results in urinary excretion of estrone at values 5-10 times the upper limit of the reference range for premenopausal women. Retrospective studies associating oral …

The importance of non-use of orally administered estrogens because of inflammatory and coagulation effects, vs no inflammation or enhanced coagulation with topical estrogens. Read More »

1 The Bioidentical Hormone Debate: Are Bioidentical Hormones (Estradiol, Estriol, and Progesterone) Safer or More Efficacious than Commonly Used Synthetic Versions in Hormone Replacement Therapy? Kent Holtorf MD. Postgrad Med 2009;121(1):1-13. Abstract: Background: The use of bioidentical hormones, including progesterone, estradiol, and estriol, in hormone replacement therapy (HRT) has sparked intense debate. Of special concern …

The importance of Estriol as it relates to lessened breast cancer risk. Also the mechanism of estriol being a prime stimulant of estrogen receptor site beta, the deproliferative step in breast glandular cell cycling. Read More »

The Bioidentical Hormone Debate: Are Bioidentical Hormones (Estradiol, Estriol, and Progesterone) Safer or More Efficacious than Commonly Used Synthetic Versions in Hormone Replacement Therapy? Kent Holtorf, MD  Abstract: Background: The use of bioidentical hormones, including progesterone, estradiol, and estriol, in hormone replacement therapy (HRT) has sparked intense debate. Of special concern is their relative safety …

The Bioidentical Hormone Debate: Are Bioidentical Hormones (Estradiol, Estriol, and Progesterone) Safer or More Efficacious than Commonly Used Synthetic Versions in Hormone Replacement Therapy? Kent Holtorf, MD Read More »